“Health and Economic Benefits of Clean Air Regulations” is a literature-based white paper that discusses the range of potential health benefits that could be gained by people of color in the three cities as a result of proposed Environmental Protection Act (EPA) regulations. The author considers the impact of reduced exposures to PM2.5 and ozone pollution, and the potential for reductions in premature deaths due to respiratory and cardiovascular conditions and lung cancer. There is also an examination of the potential reductions in asthma. One important component of this work is an expanded review of the EPA’s technical analyses of health benefits that are expected from regulations, building on existing available data. In addition to summarizing the main findings from the EPA analyses, the author evaluates the extent to which the EPA methodology addresses health benefits from an environmental justice perspective.